Memorably depressing animated film you’ve seen?

What's the saddest animated movie you've ever watched? I imply real disappointment, not low cost melodrama and sensationalism. Open to each English-language movies and international films.

I don't have one which involves thoughts, although there are particular scenes I keep in mind that made me unhappy, like a sure scene in Toy Story 3 the incinerator scene. And there are such a lot of genuinely touching scenes within the film UP that jogs my memory of my grandparents and of guarantees individuals make and desires by no means realized.

https://preview.redd.it/zk5ruvznmupd1.png?width=872&format=png&auto=webp&s=c128f2dab182bf99787d70e45d86efcb0ad8a9c0